For this week’s episode we are going to look at a brief interview I recently did with James Strole about my upcoming presentation at the RAADFEST conference in October in San Diego. While the interview is entitled ‘Extending Life with Rapamycin’, I want to be clear that:
1- the use of rapamycin is an off label use of an FDA approved prescription only drug,
2-rapamycin is a potentially dangerous drug that should only be used under the care of a physician with experience in this area, and
3- although extremely promising longevity results are present in animal models the longevity benefits of rapamycin in humans are still being determined.
As you can tell I am looking forward all the great speakers at the RAADFEST conference this fall. If are planning on attending please use code ‘LUFKIN’ at checkout for 10% off any registration.
#longevity #wellness #Ketones #lifestylemedicine #RobertLufkinMD #fasting #metabolic #exercise #raadfest #jamestrole #rapamycin #mTOR
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NOTE: This is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have. Never disregard professional medical advice or delay in seeking it because of something you have seen here.
Robert Lufkin 0:00
Welcome back to the health longevity Secret show and I’m your host, Dr. Robert Lufkin. For this week’s episode we’re going to look at a brief interview I recently did with James stroll about my upcoming presentation at the red fest conference in October in San Diego. While the interview is entitled, extending life with rapamycin, I want to be clear that one the use of rapamycin is an off label use of an FDA approved prescription only drug and to rapamycin is a potentially dangerous drug that should only be used under the care of a physician with experience in its use. And three, although extremely promising longevity results are present in animal models, the longevity benefits of rapamycin in humans are still being determined. As you can tell, I’m looking forward to all the great speakers at the RAD fest conference this fall. If you’re planning on attending, please use the code quote, Lufkin, Liu FKIN quote, at checkout for 10% off on any registration. And now, please enjoy this conversation with James stove.
James Strole 1:19
Okay, Dr. Ross, Robert luckiness. Great to have you today on this interview. Thank you for appearing. And, and thank you for all the great work you’re doing on Super longevity.
Robert Lufkin 1:29
Oh, thanks, Jim. I’m so excited to be here today. And I’m really excited about rad fast and joining everyone. This fall in October.
James Strole 1:39
Yeah, for sure. I’m very excited to meet you in person there. For those that don’t know, Dr. Lumpkin is a clinical professor at USC Keck School of Medicine. He served as the full professor at both UCLA David Geffen School of Medicine and the USC Keck School of Medicine with a current a guy academic focus on the Applied Science of longevity. Fantastic, fantastic. Chief of the metabolic imaging and a large medical network in Southern California. So your hands are full, I can see that.
Robert Lufkin 2:10
You know, it’s such an exciting time in the longevity space. It’s like, I mean, I’ve been doing this a long time, but the last 10 years, it’s been accelerating even more, and there’s so many breakthroughs. I just, I wake up each morning excited about the day and and I look forward to it. That’s it’s it’s such a it’s such a fun area to be working in. Now with everything that’s happening. As you know, as I’m sure you’re finding out at RAD fest, not only speakers there,
James Strole 2:40
they’re doing some great work and rapamycin, which you’ll be speaking extensively on rad fest. But can you give the folks a little bit of sample of you know, what, what’s being done in this field right now and that you know, will actually, you know, educate them a little bit and show them that why they need to be at RAD Fest and learn more about this. It’s very exciting to work yeah,
Robert Lufkin 2:59
sure. There are a lot of a lot of drugs and protocols that have been suggested for longevity but but one of them that stands out head and shoulders above all the others is a drug called rapamycin. And it’s interesting because it’s currently the clinically the most effective and reproducible pharmacological approach that you could that we use for directly increasing lifespan and in laboratory animals. And, and as we’ll we’ll see, it’s, it’s actually able to be used in in humans it it works on a fascinating mechanism, which basically mimics calorie caloric restriction, which is one of the oldest tried and true methods for increasing longevity, but it’s not necessarily something that’s practical for all of us to do, but it mimics that with our bodies. And then also it seems to increase something called autophagy which is very helpful for longevity also.
James Strole 4:08
Yeah, yeah. Wow, beautiful. So you actually, you’re involved I understand and a study now rapamycin, could you tell us a little bit about that?
Robert Lufkin 4:16
What we’ve done is we’re we’re putting together a registry where we contact people who are taking rapamycin for longevity, and they we ask them to report the findings and the experiences they’re having with the rapamycin as well as the dosages and their medical conditions. And these will be you know, anonymously reviewed and then we’re going to look at at some of the effects that rapamycin has as well as any of the any of the side effects of rapamycin but it’s it’s a way to get information from from human use of rapamycin that that previously wasn’t available. Actually, no one’s done this yet to look at To look at rapamycin in humans for aging in this type of registry, so we’re very excited about it.
James Strole 5:07
Yes, that is exciting. Thank you for doing this study, because we’re in such you know, we are introduced to these different protocols, but too often more often than not, we’re not getting the data to really, you know, quantify the real real results or benefits. So thank you for doing this study. To this extent, it’s very, it’s very exciting. It’s a challenge for us as humans, right? Because we can’t sit back and, and just not take every do everything we can to better our house. So we have to do like you said a plethora of things that we feel are beneficial, then sometimes, like you said, we don’t know. Unless, like, well, this is why it’s great. You’re doing this study, because you’re gonna get more people and Bob, where we can get more data otherwise, it’s hard to really determine what is really working what’s not when we’re doing all these other protocols, correct?
Robert Lufkin 5:54
Correct. Yeah, absolutely. This drug should only be given with a prescription and under a physician supervision. It’s interesting that the drug first approval was for immune suppression for renal transplant patients and many doctors who are not familiar with using rapamycin for longevity. Their only experience with rapamycin is as an immunosuppressant, which is not something you want to do to a normal patient. So they, they have a misconception about the effects of rapamycin. And they may not be familiar with the longevity uses of it, which is a completely different dosing schedule, which does not suppress your immune system. And actually, at least one study in humans has shown that it improves immune function.
James Strole 6:46
Yeah, yeah. Fantastic. Well, thank you for much so much for sharing this with us. And I’m excited, like I said, to hear you, I know you’ve got so much more to share with everybody at Red fest. And we’re going to be I think, really turned down by what you’ve got going on here. Because I myself, I mean, we’re all everybody I think listening here really wants to extend their life in a really healthy way. And if we can reverse it, we’re used to that. That’s even all the more exciting. Can you tell us though, before we end here a little bit about metabolic imaging, what that what that exactly is because I know that you’re you’re actually chief in your department for the metabolic imaging department. Can you tell us a little bit about what that is? Exactly. For longevity? I mean, that’s that’s an interesting item in itself.
Robert Lufkin 7:30
Sure. Yeah. All all the all the chronic My background is in radiology. First of all, sort of medical imaging and longevity imaging is using radiology tools to look at increasing our, our metabolic health, which translates into longevity and lifespan, because all the chronic diseases that I mentioned before, all their single greatest risk factor is age, and those are the things that kill us. And by reducing the risk factor for those diseases, we prolong our life and that increases longevity. So longevity imaging, we look at things like liver fat for fatty liver disease, we look at brain volumes for hippocampal volumes for Alzheimer’s risk. We look at obesity, we look at diabetes risk, basically, all the imaging profiles for all the chronic disease that are associated with aging.
James Strole 8:32
Oh, therefore, therefore. All right, well, maybe we’ll talk a little bit about that. I read best
Robert Lufkin 8:36
to it. Yeah, I can’t wait. Yeah, do to be at RAD Fest and hear all the other wonderful speakers there as well. And just the the opportunity to network with everybody and meet people face to face, it’s going to be great.
James Strole 8:48
So Okay, anything else you want to add before we close this interview?
Robert Lufkin 8:52
No, thanks. Thanks so much for the great work you’re doing Jim with with your program and with conferences like red fest, it’s it’s it’s really helping people understand the possibilities for longevity and the choices in their lifestyle that can improve their health and and fight aging. I’m, I’m so excited about what you’re doing.
James Strole 9:15
Thank Thank you, Robin. Appreciate it. So make sure you come to see Dr. Lufkin rad pass he’s going to be he’s going to excise with a lot of great information on rapamycin. Thanks again and we’ll see you soon. Thank you, Jim. Bye bye.
Unknown Speaker 9:30
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